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LAENNEC

Laennec is the ethical drug manufactured with JBP’s unique technologies.
Laennec is the ethical drug manufactured with JBP’s unique technologies for effective extraction of variety of growth factors, cytokines, and other physiologically active substances from the human placenta. For instance, HGF (hepatocyte growth factor) promotes the proliferation of hepatic parenchymal cells for recovery of a damaged liver. Our product safety is ensured by the most rigid safety measures among existing scientific standards.
Warning: As the LAENNEC Injection is an ethical drug, JBP has never sold it on Internet.
Ingredients
Content
Remarks
Active ingredient
Water-soluble substance of a product of enzymatic human placenta
112 mg
Ingredient extracted from human placenta
Inactive ingredients
Pepsin
Trace
Gastric mucosal extract
Lactose
0.6 mg
–
pH adjuster
q.s.
–
Description
This product is a light yellow-brown or yellow-brown clear liquid with a distinctive odor. The pH level ranges from 5.5 to 6.5 and the osmotic pressure ratio (to physiological saline) is approximately one.
Indications Improvement of hepatic function in chronic hepatic disease.
Dosage and administration The normal adult dose is a 2 ml subcutaneous or intramuscular injection once daily. According to symptoms, the dose can be increased to 2 or 3 times daily.
Packaging
2 ml 50 ampoules
Cautions for use**
1. Careful Administration
LAENNEC should be administrated with care in patients predisposed to allergies.
2. Important Basic Cautions This product is manufactured from the extract of human placenta delivered full-term in Japan. In order to screen each donor, a complete medical history, interviewing such as a history of travel and serologic testing for viruses, bacteria and infection are performed, after nucleic-acid testing (NAT) to meet with requirements for HBV-DNA, HCV-RNA and HIV-1-RNA is carried out. In addition, it has been confirmed that high-pressure steam sterilization for 20 minutes at 121 °C during the manufacturing process is effective in inactivating various viruses such as HIV etc. Furthermore, although in the product test, the nucleic-acid test meets with requirements for HBV-DNA, HCV-RNA, HIV-1-RNA, HTLV-DNA, and parvovirus B19-DNA, patients should be made aware of the following points during administration: To date, the transmission of infection, such as variant Creutzfeldt-Jakob disease (vCJD), by administration of this product in Japan or other countries has not been reported. However, although safety measures are taken to prevent infection during the manufacturing process, it is theoretically impossible to fully eliminate the risks of infection transmission originating in a human placenta used as raw material. While safety measures during the manufacturing process to prevent infection, as well as confirmation of the necessity of treatment for the disease before administration are carried out, doctors should explain to patients and try to have them understand that when human placenta is used as the raw material of a product, the risk of infection cannot be fully ruled out.
3. Drug Interactions
When this product is directly mixed with a strong base preparation of pH 8.5 or more, attenuation of pharmacological activity has been reported.
No coadministration with this product resulting in the enhancement or attenuation of the pharmacological effect of this product or concomitant drugs, appearance of adverse reactions, or aggravation of disease has been reported.
Adverse reactions or patients who were suspected to have suffered adverse reactions to this product were reported in a total of 10 (3.7 %) of the 273 patients selected for safety evaluation in the clinical study performed during implementation of reevaluation of the drug efficacy. The most frequently observed adverse reactions were injection site pain in 7 patients (2.6 %), hypersensitivity (such as rash, fever, and itching) in 1 patient (0.4 %), injection site indurations in 1 patient (0.4 %), and gynaecomastia in 1 patient (0.4 %). The causal relationship between gynaecomastia and this product is unknown.
No abnormal changes in laboratory values were observed.1)
• Clinically significant adverse reactions
**Shock (incidence unknown):
Since this product is a protein/amino acid preparation derived from human tissue, this product may cause a shock. If any signs of abnormality are observed, the drug should be discontinued immediately, appropriate measures should be taken and the condition should be monitored fully.
• Other adverse reactions (in descending order of occurrence)
Lilly –
In Japan, placental extract has been used since at least the late 1950s. The country’s National Health Insurance covers placental treatments for liver disease and menopausal symptoms. However, patients pay out of pocket for other alleged benefits, such as combating fatigue, insomnia, and aging.
The academic literature on placental extract remains limited, and its complex composition—potentially including hormones, growth factors, and immune molecules—poses risks like unwanted immune reactions or viruses. Great product.